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PARR instruments bomb calorimeter Determines energy content of food or fecal matter FLIR thermal imaging camera Determines thermal radiation

Pruthvi Swamy, M.S. Informatics Developer pseegaha [at] bidmc.harvard.edu

Our facilities were updated and re-launched as an institutional Energy Balance Core in 2019 to continue the tradition of excellence in metabolic research. This included a bomb calorimeter and a thermal imaging camera. In 2020 we obtained a Promethion indirect calorimeter and DSI’s continuous glucose...

Energy Balance Core at Beth Israel Deaconess Medical Center EnergyBalanceCore@bidmc.harvard.edu We are located in the Center for Life Science Boston 3 Blackfan Circle Boston, MA 02215

Type 2 diabetes is one of obesity’s most tightly linked comorbidities, and its prevalence is rising in parallel with the global obesity epidemic. Uncontrolled obesity often leads to insulin resistance, beta cell failure, and hyperglycemia. Although effective glucose-lowering agents, almost all...

Sable Systems Promethion indirect calorimeter (32 cages) Food intake Water intake In-cage body mass measurement Physical activity (infrared beam breaks) Energy expenditure Oxygen consumption (VO2) Carbon dioxide production (VCO2) Respiratory exchange ratio – an indicator of carbohydrate or fat...

Analysis of diet-induced obesity experiments in male C57Bl/6J mice on a low-fat diet (LFD) or high-fat diet (HFD), demonstrating differences in body weight, energy intake, expenditure, and balance (Banks et al., Nature Metabolism, 2025). ​

Optogenetic stimulation of Agrp neurons in ChR2-expressing mice was performed in the Promethion calorimeter, with food intake, metabolic rate, body temperature, and activity measured during the stimulation period.