From genome-wide association studies to etiology: probing autoimmunity genes by RNAi
Kissler, Stephan. 2011. “From Genome-Wide Association Studies to Etiology: Probing Autoimmunity Genes by RNAi”. Trends Mol Med 17 (11): 634-40.
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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes
Kissler, Stephan, Patrick Stern, Kazue Takahashi, Kara Hunter, Laurence Peterson, and Linda Wicker. 2006. “In Vivo RNA Interference Demonstrates a Role for Nramp1 in Modifying Susceptibility to Type 1 Diabetes”. Nat Genet 38 (4): 479-83.
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice
Ye, Qunrui, Barry Press, Stephan Kissler, Xiao-Feng Yang, Linrong Lu, Craig Bassing, Barry Sleckman, et al. 2002. “T Cell Costimulation through CD28 Depends on Induction of the Bcl-Xgamma Isoform: Analysis of Bcl-Xgamma-Deficient Mice”. J Exp Med 196 (1): 87-95.
Regulation of thymocyte trafficking by tagap, a GAP-domain protein linked to human autoimmunity
Duke-Cohan, JS, Ishikawa, Yoshizawa, YI Choi, Lee, Acuto, Kissler*, and EL Reinherz*. 2018. “Regulation of Thymocyte Trafficking by Tagap, a GAP-Domain Protein Linked to Human Autoimmunity”. Science Signaling 11 (534): eaan8799.
IMMUN301QC - Autoimmunity - Neoantigens
This two hour class is part of the IMMUN301QC course on Autoimmunity organized by Francisco Quintana . The class discusses the generation of neoantigens in cells that are targeted by autoimmunity. It includes a discussion of tw0 significant primary publications on this topic.
Exploring the genetic basis of disease using RNA interference
Kissler, Stephan, and Luk Van Parijs. 2004. “Exploring the Genetic Basis of Disease Using RNA Interference”. Expert Rev Mol Diagn 4 (5): 645-51.
Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice
Kissler, Stephan, Linrong Lu, and Harvey Cantor. 2004. “Thymic Selection Can Compensate for Mutations Affecting T Cell Activation and Generate a Normal T Cell Repertoire in Mutant Mice”. Proc Natl Acad Sci U S A 101 (1): 210-4.
Peripherally-induced regulatory T cells contribute to the control of autoimmune diabetes in the NOD mouse model
Schuster, Cornelia, Franziska Jonas, Fangzhu Zhao, and Stephan Kissler. 2018. “Peripherally-Induced Regulatory T Cells Contribute to the Control of Autoimmune Diabetes in the NOD Mouse Model”. European Journal of Immunology 48 (7): 1211-16.
Med-Sci 300QC - Conduct of Science discussion class
This discussion class is part of the Med-Sci 300QC Conduct of Science course for G2 DMS students. Group discussions covers all the topics of the Med-Sci300QC lectures, including conflict of interest, communication in science etc.
Stephan's short bio
Stephan received his BSc in Biochemistry and PhD in Immunology from the University of Bristol, UK. Following postdoctoral work at the Dana-Farber Cancer Institute in Boston and at the Massachusetts Institute of Technology in Cambridge, MA, Stephan became a group leader at the Rudolf Virchow Center...