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Prior studies identify brain/spinal cord regions involved in controlling bladder function, but often do not resolve neuronal subpopulations or their specific connections. We seek to develop in mice a complete circuit map of the control of bladder filling and voiding. Prior work and our own...

Lower urinary tract symptoms (LUTS) including overactive bladder, incontinence and flaccid bladder may be the most common complication for patients with diabetes, affecting up to 80–90% of patients by some estimates. We wanted to know which of the mouse strains with high blood glucose would develop...

What is the autonomic nervous system? ​ The sympathetic and parasympathetic nervous systems are two parts of the autonomic nervous system that control involuntary body functions, and organs like the kidney. The sympathetic system prepares the body for "fight or flight" responses during stress, while...

Daniel Sanchez-Almanzar, MD Dr. Sanchez-Almanzar hails from Bogota, Colombia and graduated with his MD from Universidad de Los Andes in 2021. “I have always had a great interest in urology, and during my last year in medical school I had the opportunity to work in projects on congenital...

Name Date Current Position Ali Wu, MD Erandi Velaquez-Miranda, PhD Lian Yu Guo, PhD Reina Kobayashi, DVM

In our laboratory, we investigate the finely tuned neural control mechanisms that govern voiding and continence in the bladder. Our aims are to map the circuits, create neural atlases of neuron sub-populations and then determine what each type of neuron does. Our investigators are performing basic...