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Sable Systems Promethion indirect calorimeter (32 cages) Food intake Water intake In-cage body mass measurement Physical activity (infrared beam breaks) Energy expenditure Oxygen consumption (VO2) Carbon dioxide production (VCO2) Respiratory exchange ratio – an indicator of carbohydrate or fat...

Analysis of diet-induced obesity experiments in male C57Bl/6J mice on a low-fat diet (LFD) or high-fat diet (HFD), demonstrating differences in body weight, energy intake, expenditure, and balance (Banks et al., Nature Metabolism, 2025). ​

Optogenetic stimulation of Agrp neurons in ChR2-expressing mice was performed in the Promethion calorimeter, with food intake, metabolic rate, body temperature, and activity measured during the stimulation period.

Type 2 diabetes is one of obesity’s most tightly linked comorbidities, and its prevalence is rising in parallel with the global obesity epidemic. Uncontrolled obesity often leads to insulin resistance, beta cell failure, and hyperglycemia. Although effective, many glucose-lowering agents circumvent...

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The following are examples of experiments that our core team has performed: 1. Thermogenesis: cold temperature challenge 2. Thermogenesis: beta-adrenergic agonist activation of mice housed at thermoneutral temperatures 3. Pharmacologic induction of metabolic rate (T3) 4. Diet-induced obesity 5...

Beth Israel Deaconess Medical Center and Harvard Medical School The home of CalR This is the website for the Energy Balance Core at BIDMC and Harvard Medical School, a facility designed for the measurement of energy intake, nutritional status, and energy expenditure in experimental mice. This...

Go to CalR, a web application for indirect calorimetry analysis. The CalR project: There is a critical lack of standardization for indirect calorimetry experiments to measure body composition ( Corrigan et al eLife 2020, Banks et al Nature Metabolism 2025). Currently, the same dataset can produce...

Male C57Bl/6J mice housed at thermoneutrality were administered the β-adrenergic agonist CL 316,243, and changes in oxygen consumption were continuously measured. ​

In vivo stable isotope tracing with U-¹³C₆ D-mannitol and U-¹³C₆ D-glucose was conducted to enable ¹³CO₂ monitoring in the Promethion indirect calorimeter, with data plotted using CalR for conventional (blue) and commensal-depleted (red) mice (Vieira et al., in press).