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Cooperative binding of calcium to thrombospondin. The effect of calcium on the circular dichroism and limited tryptic digestion of thrombospondin.

Publication: Journal Article

Lawler, J, and E R Simons. 1983. “Cooperative Binding of Calcium to Thrombospondin. The Effect of Calcium on the Circular Dichroism and Limited Tryptic Digestion of Thrombospondin.”. The Journal of Biological Chemistry 258 (20): 12098-101.

Thrombospondins in the tumor microenvironment.

Publication: Journal Article

Petrik, James, Sylvia Lauks, Bianca Garlisi, and Jack Lawler. 2024. “Thrombospondins in the Tumor Microenvironment.”. Seminars in Cell & Developmental Biology 155 (Pt B): 3-11.

Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer.

Publication: Journal Article

Matuszewska, Kathy, Lisa A Santry, Jacob P van Vloten, Amanda W K AuYeung, Pierre P Major, Jack Lawler, Sarah K Wootton, Byram W Bridle, and Jim Petrik. 2019. “Combining Vascular Normalization With an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer.”. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 25 (5): 1624-38.

Clinical Development of Fc3TSR

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TSP-1 is a critical anti-angiogenic protein that counterbalances the pro-angiogenic activity of various factors, including VEGF, in normal physiology. Solid tumors are characterized by a tortuous vasculature, reduced perfusion, hypoxia, and high interstitial fluid pressure which impairs entry of...

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Recent Review Articles on the Thrombospondins Thrombospondin-1 in vascular development, vascular function, and vascular disease. Liu B, Yang H, Song YS, Sorenson CM, Sheibani N. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):32-44. doi: 10.1016/j.semcdb.2023.07.011. Epub 2023 Jul 27. PMID: 37507331...