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Evan Rosen Lab Division of Endocrinology, Diabetes, and Metabolism Beth Israel Deaconess Medical Center Center for Life Sciences, 7th floor 3 Blackfan Circle Boston, MA 02115 E: erosen@bidmc.harvard.edu Admin: Zain Nichols E: znichols@bidmc.harvard.edu T: 617-735-3322 F: 617-735-3223

Thrombospondin Structure

Five members of the TSP gene family have been identified (Fig. 1). TSP-1 and -2 (Subgroup A) are similar in their domain structure and the fact that they form disulfide-linked trimers. By contrast, TSP-3 and -4, and cartilage oligomeric matrix protein (COMP) (Subgroup B) assemble into pentamers. An...

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