For several years, we have been exploring the factor-of-risk concept to understand the unique pathophysiology of vertebral fractures. Using computed tomography (CT) scans from the Framingham Heart Study, we have explored the relationship between spinal curvature, trunk muscle, and vertebral strength and vertebral fracture. Pipelines for analyzing CT images are constantly being updated, and advanced image processing techniques are utilized.
Additionally, we have developed methods for creating complex subject-specific biomechanical models that can be used to estimate internal spine loads. Recent work has been done to validate these models for dynamic activities, though clinical feasibility of these models is still a work-in-progress.
Recent Publications
Alemi, M. M., Banks, J. J., Lynch, A. C., Allaire, B. T., Bouxsein, M. L., & Anderson, D. E. (2023). EMG validation of a subject-specific thoracolumbar spine musculoskeletal model during dynamic activities in older adults. Annals of Biomedical Engineering, 51(10), 2313-2322.
Banks, J. J., Alemi, M. M., Allaire, B. T., Lynch, A. C., Bouxsein, M. L., & Anderson, D. E. (2023). Using static postures to estimate spinal loading during dynamic lifts with participant-specific thoracolumbar musculoskeletal models. Applied Ergonomics, 106, 103869.
Johannesdottir, F., Allaire, B., Kopperdahl, D. L., Keaveny, T. M., Sigurdsson, S., Bredella, M. A., ... & Bouxsein, M. L. (2021). Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture location. Osteoporosis International, 32, 261-269.
Anderson, D. E., Burkhart, K., Alemi, M. M., & Bouxsein, M. L. (2021). Biomechanics of hip and vertebral fractures. In Marcus and Feldman's Osteoporosis (pp. 357-378). Academic Press.
Kaiser, J., Allaire, B., Fein, P. M., Lu, D., Adams, A., Kiel, D. P., ... & Morgan, E. F. (2020). Heterogeneity and spatial distribution of intravertebral trabecular bone mineral density in the lumbar spine is associated with prevalent vertebral fracture. Journal of Bone and Mineral Research, 35(4), 641-648.