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Hedonic Capacity, Psychosocial Interventions and Outcomes in Schizophrenia
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Biorepository
This project aims to establish a repository of biosamples in patients with varying neurologic disorders. The proposed biorepository aims to collect a variety of high-quality biosamples and relate them to clinical information to support the accelerated identification of disease biomarkers for earlier...
Functional Characterization of the Autophagy-Lysosomal Dysfunction in AD and PD
We have successfully identified multiple novel genetic associations between AD and common and rare variants in endolysosomal genes ( PLD3, RAB10, GRN12, TMEM106B, CPAMD8, MS4A4A). Recently, we performed a systematic, comprehensive evaluation of the contribution of coding variants in each...
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Thrombospondin Function
TSP-1 is released from human blood platelets in response to thrombin treatment and was thus, designated thrombospondin in 1978. Since that time, four other members of the TSP gene family have been discovered. The TSPs are widely expressed in embryonic tissue. However, expression in adult tissue is...