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Alexander S. Banks Beth Israel Deaconess Medical Center Division Of Endocrinology, Diabetes, and Metabolism Center for Life Sciences, 7th floor 330 Brookline Ave Boston, MA 02115 Email: asbanks [at] bidmc.harvard.edu
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Jack Lawler's thrombospondin research
The Lawler lab's in-depth knowledge of thrombospondin (TSP) structure and function has led to the development of a novel therapeutic for the treatment of ovarian and pancreatic cancer.
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Research
The Lawler lab has studied the structure and function of the members of the TSP gene family for more than 50 years. We have focused on the role of TSP-1 in the tumor microenvironment. This research has informed the development of a new cancer therapeutic that is currently being evaluated in murine...
Pharmacologic induction of metabolic rate (T3)
C57Bl/6J male mice were monitored in the Promethion indirect calorimeter, and data were analyzed in CalR to compare energy expenditure between T3-treated and vehicle groups (Hochbaum et al., Cell, 2024).
Chemogenetic stimulation of metabolism
Mice expressing DREADDs and non-DREADD controls were monitored in the Promethion indirect calorimeter, with CNO administered at hour 4 and data plotted in CalR.
Induction of torpor
C57Bl/6J female mice were monitored for body temperature and metabolic rate during the dark photoperiod without food, with the blue trace representing a fed mouse and the red trace a fasted mouse exhibiting torpor (Hrvatin et al., Nature 2020).