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Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that work–or citations. Selected highly...

The Kim Laboratory investigates molecular and physiological mechanisms that regulate glucose and energy homeostasis, with a focus on pathways that are disrupted in obesity, type 2 diabetes and fatty liver disease. We concentrate on key signaling nodes, including the kinase ROCK1, the lipoprotein...

C57Bl/6J male mice were monitored in the Promethion indirect calorimeter, and data were analyzed in CalR to compare energy expenditure between T3-treated and vehicle groups (Hochbaum et al., Cell, 2024).

Mice expressing DREADDs and non-DREADD controls were monitored in the Promethion indirect calorimeter, with CNO administered at hour 4 and data plotted in CalR.

C57Bl/6J female mice were monitored for body temperature and metabolic rate during the dark photoperiod without food, with the blue trace representing a fed mouse and the red trace a fasted mouse exhibiting torpor (Hrvatin et al., Nature 2020). ​

Wheel-running activity was continuously recorded over several days, showing hourly running patterns and cumulative wheel counts across alternating light and dark cycles. ​

Alexander S. Banks Beth Israel Deaconess Medical Center Division Of Endocrinology, Diabetes, and Metabolism Center for Life Sciences, 7th floor 330 Brookline Ave Boston, MA 02115 Email: asbanks [at] bidmc.harvard.edu