Welcome! Our current projects are featured below.
We are dedicated to unraveling the intricacies of Parkinson's disease pathogenesis. By focusing on mechanisms of neurodegeneration and innovative approaches to neuroprotection, we strive to make significant contributions to the understanding and treatment of Parkinson's.
The VPS35 Gene
A rare VPS35 gene mutation causes familial PD
Illustration by Il-Sun Wu in (Kim et al., 2017)
This transcriptional coactivator is a key regulator of cellular energy metabolism
Illustration from (Cardanho-Ramos & Morais, 2021)
USP30 and Mitophagy
USP30 inhibits mitophagy by removing ubiquitin attached by PARKIN or other E3 ligases
USP30 is a deubiquitinating enzyme (DUB) and could be a potential target for regulating mitophagy and modifying disease progression in PD.