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Dr. Chenxi Qiu

Person: Assistant Professor

Dr. Qiu is a molecular neuroscientist with a genomics background. Dr. Qiu’s primary interest is to develop and employ genomic tools to determine how traumatic or vascular brain injuries lead to cognitive impairment and dementia. Work with the Zeidel lab involves use of integrative systems...

Lab members excited to head to Bar Harbor, Maine to teach students nephrology in lab-based curriculum

News: June 07, 2025

This intensive one week course in June at the beautifully situated Mount Desert Island Biological Laboratory is titled "Origins of Renal Physiology for Medical Students". Sponsored by the American Society of Nephrology. The course is designed to engender an understanding of and appreciation for...

Dr. Chenxi Qiu receives new funding to study a novel treatment option for dementia

News: October 14, 2025

Entitled ' Cis P-tau conformation-specific antibody for treatment of vascular dementia' Dr. Qiu aims to evaluate a promising therapeutic antibody for the treatment of vascular dementia, the second most common form of dementia. Vascular dementia is a type of dementia caused by reduced blood flow to...

Congratulations to Dr. Hanneke Verstegen on her new RO1 grant from NIH

News: November 17, 2025

Entitled: Mapping mechanosensory circuits from the bladder to Barrington's nucleus Open positions for interested and motivated candidates Detecting sensations from within our bodies, a process called interoception, is critical to drive many physiological processes. Stretch signals from the bladder...

Bladder Projects

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In our laboratory, we investigate the finely tuned neural control mechanisms that govern voiding and continence in the bladder. Our aims are to map the circuits, create neural atlases of neuron sub-populations and then determine what each type of neuron does. Our investigators are performing basic...

Single Cell RNA-seq Identification of Neuron Populations Controlling Bladder Function

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Modern transgenic “tools” enable specific neuron populations to be mapped, monitored, and manipulated in vivo. While these approaches represent an enormous advance, their application requires knowledge of specific transcriptional markers for distinguishing the neurons of interest from their...

Results

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Results - Obtained Under Urethane Anesthesia Regions that show activation during CMG peak include the Pontine Micturition Center (PMC), the Periaqueductal Gray (PAG) and the Hypothalamus. The PMC is a small center in the hindbrain that we now know activates bladder contractions, whereas the PAG...

Team

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Team And Collaborators: Mark Zeidel, MD, Principal Investigator Bryce MacIver, PhD, Project Coordinator Aaron Grant, PhD, Director, Preclinical MRI Core at BIDMC Dave Alsop, PhD, Director, Division of Magnetic Resonance Research at BIDMC Cody Callahan, BS, Department of Radiology at BIDMC John Mac...

Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser.

Publication: Journal Article

Lin, Guowu, Christopher O Barnes, Simon Weiss, Bercem Dutagaci, Chenxi Qiu, Michael Feig, Jihnu Song, et al. 2024. “Structural Basis of Transcription: RNA Polymerase II Substrate Binding and Metal Coordination Using a Free-Electron Laser.”. Proceedings of the National Academy of Sciences of the United States of America 121 (36): e2318527121.

Characterization of RNA polymerase II trigger loop mutations using molecular dynamics simulations and machine learning.

Publication: Journal Article

Dutagaci, Bercem, Bingbing Duan, Chenxi Qiu, Craig D Kaplan, and Michael Feig. 2023. “Characterization of RNA Polymerase II Trigger Loop Mutations Using Molecular Dynamics Simulations and Machine Learning.”. PLoS Computational Biology 19 (3): e1010999.