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Mapping Brainstem Control of Bladder Filling and Voiding
Prior studies identify brain/spinal cord regions involved in controlling bladder function, but often do not resolve neuronal subpopulations or their specific connections. We seek to develop in mice a complete circuit map of the control of bladder filling and voiding. Prior work and our own...
The Kidneys and the Brain
What is the autonomic nervous system? The sympathetic and parasympathetic nervous systems are two parts of the autonomic nervous system that control involuntary body functions, and organs like the kidney. The sympathetic system prepares the body for "fight or flight" responses during stress, while...
Postdoctoral Research Fellows
Daniel Sanchez-Almanzar, MD Dr. Sanchez-Almanzar hails from Bogota, Colombia and graduated with his MD from Universidad de Los Andes in 2021. “I have always had a great interest in urology, and during my last year in medical school I had the opportunity to work in projects on congenital...
John C Mathai, PhD
About Us
Bladder Projects
In our laboratory, we investigate the finely tuned neural control mechanisms that govern voiding and continence in the bladder. Our aims are to map the circuits, create neural atlases of neuron sub-populations and then determine what each type of neuron does. Our investigators are performing basic...
Single Cell RNA-seq Identification of Neuron Populations Controlling Bladder Function
Modern transgenic “tools” enable specific neuron populations to be mapped, monitored, and manipulated in vivo. While these approaches represent an enormous advance, their application requires knowledge of specific transcriptional markers for distinguishing the neurons of interest from their...