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Our team collaborates on the Tsimane Health and Life History Project to investigate how lifestyle, physical activity, and diet influence musculoskeletal health across the lifespan. Studying the Tsimane—an Indigenous forager-horticulturalist population in the Bolivian Amazon—provides unique insights...

Micro-computed tomography (microCT) is an imaging technique that uses x-rays to produce cross-sectional images of an object that can be reconstructed to create a three-dimensional model. It allows for non-destructive quantitative analysis of the density, geometry and microarchitecture of mineralized...

As part of our assessment of tissue properties, we perform microindentation using a BioDent tester, which is a novel reference point indentation device developed by ActiveLife Scientific. Reference Point Indentation enables assessment of bone material properties without requiring special surface...

Osteoporosis remains underdiagnosed and undertreated. Current clinical standards have low sensitivity because half of all fracturesoccur in individuals without osteoporosis based on bone density testing and/or with few clinical risk factors. Photon-counting computed tomography (PCCT) is an emerging...

We recognize the value of collaborations and are proud of our many collaborators, both current and past. Collaboration is at the heart of scientific progress, and we are happy to highlight some of our collaborations below: San Francisco Coordinating Center, The Osteoporotic Fractures in Men (MrOS)...

Our research focuses on mitigating the deleterious effects of spaceflight on the skeleton. Using both clinical investigations in astronauts and experimental studies in animal models, we examine how microgravity disrupts bone remodeling, compromises skeletal integrity, and alters cellular and...

One in two women and one in four men over the age of 50 will suffer a fragility fracture in their remaining lifetime. These fractures lead to profound morbidity, increased mortality and high personal and societal costs. While effective treatments are available, they do not prevent all fractures and...