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Modern transgenic “tools” enable specific neuron populations to be mapped, monitored, and manipulated in vivo. While these approaches represent an enormous advance, their application requires knowledge of specific transcriptional markers for distinguishing the neurons of interest from their...

Results - Obtained Under Urethane Anesthesia Regions that show activation during CMG peak include the Pontine Micturition Center (PMC), the Periaqueductal Gray (PAG) and the Hypothalamus. The PMC is a small center in the hindbrain that we now know activates bladder contractions, whereas the PAG...

Prior work by others suggests that renal nerves arise from several neuron subpopulations in sympathetic ganglia. It is possible that these specific subpopulations of neurons, as well as the CNS circuits that innervate them selectively control tubular transport, glomerular filtration rate or renin...

Functional MRI Processing for Mouse Micturition Studies Functional MRI (fMRI) studies in rodents is somewhat uncommon as it requires some cognitive or physiological stimulus that causes measurable changes in brain activity. This project however, lends itself well to fMRI studies as voiding induced...

Team And Collaborators: Mark Zeidel, MD, Principal Investigator Bryce MacIver, PhD, Project Coordinator Aaron Grant, PhD, Director, Preclinical MRI Core at BIDMC Dave Alsop, PhD, Director, Division of Magnetic Resonance Research at BIDMC Cody Callahan, BS, Department of Radiology at BIDMC John Mac...

These studies were funded by an NIH P20 grant [DK108276], to form a Resource Development Project within the BIDMC Department of Medicine’s Center for Interdisciplinary Research in Benign Urology. This Project brings together Department of Radiology Magnetic Resonance Imaging (MRI) physicists and...