Schiroli, G., & Genovese, P. (2026). A 3D "nichoid" boost for gene-engineered blood stem cells.. Cell Stem Cell, 33(2), 167-169.
Abstract
Midena et al.1 employ a nanoengineered 3D "nichoid" substrate that mechanically supports CD34+ hematopoietic stem and progenitor cells (HSPCs) during ex vivo manipulation, reducing culture-associated stress and improving engraftment and polyclonal output after gene editing or lentiviral gene addition. The work spotlights mechanobiology as a manufacturing lever for improving HSPC gene therapies.