Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells.

McAlindon, C. A., & Clark, R. A. (2026). Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells.. Science Immunology, 11(116), eaef9196.
Publisher's Version

Abstract

Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and drive T cell exhaustion.

Last updated on 04/02/2026
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