Abstract
Clinical trials are contingent upon enrollment of participants who are willing to volunteer their time and effort. Many persons living with HIV (PLWH) are long-term survivors aging into midlife and thus, are at risk for medical co-morbidities such as cardiovascular disease (CVD). Many PLWH have a long-standing history of research participation, including therapeutic trials, which have informed the use of highly effective antiretroviral treatments. As increasing numbers of PLWH age, research participation remains essential to generate findings to inform clinical care and treatment guidelines for aging-associated diseases specific to this population. Our study shares findings from survey data that explored reasons for clinical research participation, including participation in a CVD risk study, among midlife PLWH. Four themes emerged from content analysis of the participant responses: health and wellness, research engagement, altruism, and personal benefit. Findings may inform strategies to enhance recruitment and retention strategies for research studies among midlife PLWH.