Wang, L., Sardella, B. R., Aronson, E. K., Liu, Z., Li, X., Wulf, G. M., & Heng, Y. J. (2026). Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2mut breast tumors.. NPJ Breast Cancer, 12(1), 27.
Abstract
We utilized the K14-Cre Brca1f/fTp53f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating BRCA1/2-related tumors, but this combination is not sufficient to prevent carcinogenesis.