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TSP-1 is a critical anti-angiogenic protein that counterbalances the pro-angiogenic activity of various factors, including VEGF, in normal physiology. Solid tumors are characterized by a tortuous vasculature, reduced perfusion, hypoxia, and high interstitial fluid pressure which impairs entry of...

Recent Review Articles on the Thrombospondins Thrombospondin-1 in vascular development, vascular function, and vascular disease. Liu B, Yang H, Song YS, Sorenson CM, Sheibani N. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):32-44. doi: 10.1016/j.semcdb.2023.07.011. Epub 2023 Jul 27. PMID: 37507331...

The Lawler lab has studied the structure and function of the members of the TSP gene family for more than 50 years. We have focused on the role of TSP-1 in the tumor microenvironment. This research has informed the development of a new cancer therapeutic that is currently being evaluated in murine...

Our studies on the effects of Fc3TSR in a preclinical model of pancreatic cancer were recently reported at the September AACR meeting in Boston. Abstract A040: Assessing the ability of Fc3TSR to remodel the tumor microenvironment and enhance efficacy of immunotherapeutics and chemotherapy in a...

TSP-1 is released from human blood platelets in response to thrombin treatment and was thus, designated thrombospondin in 1978. Since that time, four other members of the TSP gene family have been discovered. The TSPs are widely expressed in embryonic tissue. However, expression in adult tissue is...

Five members of the TSP gene family have been identified (Fig. 1). TSP-1 and -2 (Subgroup A) are similar in their domain structure and the fact that they form disulfide-linked trimers. By contrast, TSP-3 and -4, and cartilage oligomeric matrix protein (COMP) (Subgroup B) assemble into pentamers. An...