A neuroscience postdoctoral training fellowship is available in the laboratory of Elizabeth Engle, MD, Professor of Neurology and Ophthalmology at Harvard Medical School (HMS) and HHMI Investigator at Boston Children’s Hospital (BCH). The Engle lab has found that cranial motor neurons provide a powerful model system for the study of Mendelian coding and noncoding genetics and mechanisms of neuronal development and connectivity. Thus, the lab identifies congenital human neurodevelopmental disorders of eye and facial movement, defines their genetic etiologies, and uncovers molecular pathways and disease mechanisms. This informs determinants of motor neuron identity and the targeting of their axons during normal and abnormal development. For more information about the lab: http://kirbyneuro.org/EngleLab/

The successful postdoctoral applicant will have the opportunity to define disease mechanisms underlying human disorders of microtubule and kinesin function through the study of novel mouse models. In addition to professional development opportunities within the lab, the fellow will have ample opportunities to take advantage of the vibrant scientific community of BCH, HMS and its affiliated hospitals, and the Broad Institute of MIT and Harvard.