NOTE: The schedule below and talk titles are subject to change below and are not finalized
Welcome & Introductions
Dr. Pamela Marino, Chief, Biochemistry and Biorelated Chemistry Branch, PPBC, NIGMS, National Institutes of Health
Background and data needs for setting research priorities
8:30 a.m.,
Dr. Chris Lynch, Director, Office of Nutrition Research, NIDDK & Chief, Nutrition Research Branch, DDN, NIDDK, National Institutes of Health
Dr. Kellie O. Casavale, Senior Nutrition Advisor, Office of Nutrition and Food Labeling
Center for Food Safety and Applied Nutrition, FDA
Dr. Daniel J. Raiten, Program Director, Nutrition Pediatric Growth and Nutrition Branch,
NICHD, National Institutes of Health
Synthesis & Analysis of HMO’s
9:00 a.m.,
Challenges in the Chemical Synthesis of Human Milk Oligosaccharides at Multiple Scales
Dr. Nicola Pohl, Professor of Chemistry and Joan and Marvin Carmack Chair in Bioorganic Chemistry, Department of Chemistry, Indiana University
9:30 a.m.,
Automated chemical synthesis of human milk oligosaccharides
Dr. Alexei V. Demchenko, Curators’ Distinguished Professor, Chair-Elect, American Chemical Society CARB Division, Department of Chemistry and Biochemistry, University of Missouri – St. Louis
10:00 a.m.,
Break
10:30 a.m.,
Chemoenzymatic Synthesis of Comprehensive Libraries of Human Milk Oligosaccharides”
Dr. Anthony Prudden & Dr. Geert-Jan Boons, Complex Carbohydrate Research Center, University of Georgie, Athens, Ga
11:00 a.m.,
Access to HMO chemical space through chemical and enzymatic synthesis
Dr. George Peng Wang, Professor & GRA Eminent Scholar, Department of Chemistry, Georgia State University
11:30 a.m.,
Human milk oligosaccharide structures and synthesis by one-pot multienzyme (OPME) strategies
Dr. Xi Chen, Professor, Department of Chemistry, University of California-Davis
12:00 p.m.,
Working Lunch
1:00 p.m.,
Decoding the Detailed Structure and Composition of Milk Oligosaccharides
Dr. Parastoo Azadi, Technical Director, Complex Carbohydrate Research Center, University of Georgia
1:30p.m.,
Functional Glycomics of Natural Glycans
Dr. David Smith, Professor Department of Biochemistry, Emory University School of Medicine
2:00p.m.,
Studies of the Molecular Recognition of HMOs
Dr. Mark Jones, Staff Scientist, & Dr. Richard Cummings, Professor of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center
2:30p.m.,
Speakers Round Table Discussion
Leader, Dr. Mark Lowenthal, Chemist, Bioanalytical Science Group, NIST
Discussion Questions:
Have we defined the chemical space for HMO’s? Can we synthesize this space? Do we have appropriate standards for HMO’s? Do we have appropriate assays to assess their bioactivity? Do we need additional screening tools?
3:00p.m., Wrap up and adjourn